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Description

By downregulating NFE2L2 and inhibiting the nuclear receptor subfamily 2 group F member 6/KEAP1 signaling pathway, apatinib has been demonstrated to induce ferroptosis in glioma cells

Kellen E, Hemelt M, Broberg K, Golka K, Kristensen VN, Hung RJ, et al

Antioxidant Effects MB activates the Nrf2 pathway , a master regulator of antioxidant defense

This article systematically reviews the progress of photodynamic therapy, the mechanism of action of light-activated prodrugs, the coupling strategies between prodrugs and photosensitizers (including covalent bonds and non-covalent bonds), and the clinical translation challenges of light-activated prodrug systems