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This makes it a natural choice for researchers transitioning between these two levels or for those on a slower escalation schedule who prefer smaller dose increments

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This is experimental territory, and treating it otherwise would be irresponsible

Periorbital hyperpigmentation can be caused by shallow vascularization or thin skin in the infraorbital region, hyperpigmentation due to atopic or contact dermatitis, familial predisposition, symptomatic tear troughs, localized shadowing from skin laxity, excessive sun exposure, smoking, sleep deprivation, and fatigue (Citation2,Citation8)

AOD-9604 has less-established evidence but fewer known side effects

Poison center cases, emergency department visits, and emergency medical service responses related to recreational nitrous oxide misuse -- Michigan, 2019 to 2023