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These receptor proteins are characterized by the presence of LIR motifs for the interaction with ATG8 family proteins such as LC3 on the surface of phagophores, and many have ubiquitin-binding domains capable of recognizing ubiquitinated cargo, thus establishing a bridge between the cargo and the autophagic machinery (92, 93)

However, some of them may be used to patch holes in leaky intestinal wall, which is characterized by increased specific permeability of the intestinal epithelium

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This approach addresses the copper peptide and retinol question from a fundamentally different angle