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Copper homeostasis plays pivotal roles in physiological processes, requiring precise regulation through an integrated network of copper-dependent proteins including transporters, chaperones, and enzymes ( The antioxidant glutathione (GSH) emerged as another critical mediator in DEXs protective mechanism

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"It is challenging to determine the true level of the patient's pain because somebody may say their pain is 8 out of 10

doi: 10.1016/j.prp.2007.10.008