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Once neutral lipids accumulate between the ER membrane leaflets and reach a critical concentration (2.810 mol%), seipin (BSCL2) and its binding partner, promethin (LDAF1) nucleate LDs at discrete ER subdomains, trapping TG molecules and promoting their phase separation into lens-like structures (Joshi and Cohen 2019

Pelargonidin also decreases the DNA methylation in the Nrf2 promoter region, and increases expression of downstream target genes of Nrf2 e.g

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We acknowledge the grant support from the Department of Biotechnology-Basic Research in Modern Biology DBT (BRB): BT/PR8226/BRB/10/1224/2013, Department of Science and Technology-The Science and Engineering Research BoardExtra Mural Research DST-SERB-EMR: EMR/2017/005381, Department of Biotechnology- Bioinformatics Infrastructure facility DBT-BIF: BT/BI/25/063/2012, Department of Science and Technology- Fund for improvement of Science and Technology Infrastructure in Higher Educational Institutions (DST-FIST): SR/FST/LSI-616/2014, University Grants Commission-Special Assistance Program (UGC-SAP III): F.3-19 /2018/DRS-III(SAP-II) for infrastructure funding

It is important to note that ipamorelin is strictly for research purposes only