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These molecules were subjected to preparation in LigPrep (15) generating their ionization states at pH 7.0 (2.0) using Epik ionizer, and three lowest energy conformers were retained for each compound

Wang RM, Christman KL

Increase in echogenicity of echolucent carotid plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled, randomized trial