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Vitamin C [3] is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons

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Researchers have found that human proximal tubule epithelial cell lines exhibited distinct ultrastructural alterations indicative of pyroptosis when exposed to high glucose, and that the expression of TLR4, NLRP3, caspase-1, GSDMD-N, IL-1, and IL-18 are significantly upregulated (124)

10.1002/mnfr.201600422 Mol

In contrast, microglia in close proximity to amyloid plaques (fluorescent Congo-red derivative, methoxy-XO4 positive, XO4 + ) and those distant from plaques (XO4 ) have been isolated and analyzed from AD model mice