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Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

Yandim et al., 2013

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During ischemia, ATP depletion causes breakdown of cellular cytoskeleton, loss of cell polarity, and activation of death pathways

Koopman R, Verdijk LB, Beelen M, Gorselink M, Kruseman AN, Wagenmakers AJ, Kuipers H, van Loon LJ

Based on these findings, it is hypothesized that IL-17A inhibitors may improve intestinal inflammation in PSO patients by increasing the abundance of Eubacterium_hallii_group , which promotes SCFA production while increased Parasutterella promotes hypoxanthine production and regulates BAs metabolism in patients, which in turn improves intestinal barrier function and achieves the relief of clinical symptoms