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Sometimes its due to hormonal imbalances, particularly when oestrogen and progesterone levels are out of sync

doi:10.1136/gut.2005.084954 [13] Iwata K

Pinpointing the cause is a huge step forward, and thankfully, the path to feeling better is often straightforward and very effective

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Ab68 may exert its anti-inflammatory effects by preventing CD38 from binding to its cognate receptor CD31, thereby reducing CD38 + immune cell adhesion to endothelium and CD31-mediated transmigration to sites of inflammation 52,56,57