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Gut dysbiosis, characterized by microbial composition and function alterations, contributes to systemic inflammation and metabolic imbalances, exacerbating CKD progression

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doi: 10.1111/acel.2015.14.issue-5 Summary Keywords oxidative stress, sperm dysfunction, reactive oxygen species, DNA fragmentation and male infertility, male infertility Citation Wang Y, Fu X and Li H (2025) Mechanisms of oxidative stress-induced sperm dysfunction

Additionally, dysfunctional Nrf2 cannot effectively regulate immune responses, leading to the excessive release of inflammatory factors, which worsens joint inflammation and damage

Mice had access to food and water ad libitum, except during the behavioural tests

These grading scales include the Ajani Sensory, Eastern Cooperative Oncology Group (ECOG), National Cancer InstituteCommon Terminology Criteria for Adverse Events (NCICTCAE), and World Health Organization (WHO) systems, which grade CIPN severity on a scale of 0 (normal) to 5 (death)