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The input for other information, e.g., scan cycles and time duration, may be needed as well

Supporting the immune system

BRD4 recruits G9a (EHMT2) to ATG loci such as WIPI1 , GABARAPL1, LAMP1 , and CTSD , promoting H3K9 dimethylation and transcriptional repression

LC3, Light chain 3

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In summary, intervertebral disc degeneration manifests as a comprehensive deterioration of the microenvironment, including increased ECM stiffness, reduced nutrients, increased acidity, hypoxia, and exacerbated inflammatory response