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In this study, Clementi et al observed higher eryptosis levels in patients with advanced CKD (stage G4 and stage G5), compared with early stages of chronic renal damage (stage G1, G2, and G3) [260]

Those who received only Alimta and cisplatin had a median survival of 16.1 months

In cells, Fe 3+ is reduced again to Fe 2+ by ferric reductase, and Fe 2+ is released into the labile iron pool (LIP) [32]

Cancer / proliferation concern: Potentiating c-Met (a proto-oncogene product) raises a legitimate theoretical risk of promoting pre-existing or nascent malignancy

Cancer Lett 120:14956, PMID: 9461031 Campos AC, Molognoni F, Melo FH, Galdieri LC, Carneiro CR, DAlmeida V, Correa M, Jasiulionis MG (2007) Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation

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