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GA decreases the activity of catalase (CAT), ascorbate peroxidase (APX), and superoxide dismutase (SOD), leading to reduced scavenging ability for ROS, consequently resulting in peroxidative damage of membranes followed by release of hydrolytic enzymes (Jones and Smirnoff, 2005

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10.1161/JAHA.120.018633 Summary Keywords intracranial aneurysm, DNA methylation, mRNA expression, 5-aza-2'-deoxycytidine, glutathione S-tranferase alpha 4 Citation Xu T, Yu X, Zhou S, Wu Y, Deng X, Wu Y, Wang S, Gao X, Nie S, Zhou C, Sun J and Huang Y (2023) DNA methylation and mRNA expression of glutathione S-transferase alpha 4 are associated with intracranial aneurysms in a gender-dependent manner

Once the reaction rate has met the minimum requirement, efforts should be put on improving the non-covalent binding contribution

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Chavarria C, Rodriguez-Bottero S, Quijano C, Cassina P, Souza JM (2018) Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons