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Despite studies investigating the antifibrotic potential of TGF/Smad inhibition, we believe that the early induction of TGF-mediated fibrosis by fibroblast injection intervention in the acute and subacute stages of IDD will benefit patients by stabilizing and maintaining disc height to minimize the loss of biomechanical functions of the intervertebral disc

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Blow RD, Boor P (2019) Extracellular matrix in kidney fibrosis: more than just a scaffold

Since metastasis is a multi-step process, the metastatic cells will need some properties to overcome hindrances, and the ability to survive in detached conditions, to invade, and to form new tumours

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