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Conservative treatment is primarily suitable for early-stage IVDD, with the primary goal of alleviating symptoms to improve quality of life

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50 Sagawa M, Takao M, Nogawa S, Mizuno M, Murata M, Amano T, et al

The pentameric LAMTOR complex was the first identified GEF for RagA/B and their interaction was shown to be dependent on AA and the v-ATPase (Zoncu et al., 2011

CD3, PHOX2B and HLA-ABC antibodies were used at 1:100, 1:500 and 1:1,200 dilutions, respectively

Conclusion: Here we report a novel function of portal fibroblasts as drivers of cholestatic fibrosis, ductular reaction, inflammation, hepatocyte senescence, and HCC in aged mice, demonstrating the key role of the tumor microenvironment