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It is likely that the somatostatin actions are dependent on the density and distribution of SST receptor subtypes in different tissues ( Figure 2 Intra-islet actions of somatostatin The human pancreas includes 1-3 million pancreatic islets ( Figure 1 )

But I assure you that listeners of this podcast are familiar with drinking from the fire hose of mechanism, and that was really helpful

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M2 receptors were lower in bipolar depressed patients compared to patients with major depression and healthy controls [223]

Addenda to this rule can be found on the CMS OPPS web page

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