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MDHA, which is unstable and quickly converted to DHA, is reduced and recapitulates ascorbate by MDHAR using NADH or NADPH

Clinically, this manifests as declining free T4 and free T3 levels on serial testing despite stable thyroid hormone doses after starting Sermorelin

Thus, a diminished activity of the Prdx2 antioxidant system may be a contributor to G6PD-related diseases, and this could also be dependent on the G6PD genetic variant

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Increased zinc consumption results in increased thionein synthesis in the enterocyte