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Berberine is a plant alkaloid that activates AMPK and modestly improves insulin sensitivity and lipids

Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144

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After 1 h incubation with secondary antibody solution, membranes were imaged using the femtoLUCENT PLUS-HRP Kit (G-Biosciences) in a Qiagen ChemiDoc TM imaging chamber