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Consistent with this, AI-based structural prediction 74 indicated a direct interaction between NHR-49 and XPO-1 that required its small GTPase cofactor RAN-1 (ipTM = 0.66 versus 0.54 without RAN-1) (Fig

For example, James et al

Moreover, also iodine deficiency has been associated with increased autoimmunity [7, 25, 26], Overall, the benefits of iodine prophylaxis largely outweighing the risks, and a possible increase in thyroid autoimmunity should not represent a limitation to promoting iodine supplementation in the general population [25, 26, 29]

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The residues selenium-cysteine (U) or cysteine (C) at the active site, together with glutamine (Q) and tryptophan (W), forms the signature catalytic triad of the glutathione peroxidase family 30

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