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The final step of the oxPPP pathway, which produces the second molecule of NADPH, is catalysed by 6-phosphogluconate dehydrogenase (6PGD)

However, cipemastat, a selective MMP inhibitor, paradoxically increased cavitation, immunopathology, and mortality in a murine model of cavitary TB [139]

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PA-treated cells exhibited an increased mitochondrial ROS production, which was abrogated by fer-1, validating the important role of mitochondrial ROS in PA-induced ferroptosis only for SUM-159 cells (Figs