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Hence, Chen et al

Another clinical study (NCT00913562) aimed to assess whether rosuvastatin could improve endothelial function in these patients, using flow-mediated vasodilatation of the brachial artery and flicker-induced vasodilatation of retinal vessels

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used IL-1 receptor antagonist to antagonize IL-1, which reversed BBB damage and cognitive impairment after brain oxidative damage, confirming that IL-1 is an important factor mediating cognitive impairment in sepsis (Mina et al., 2014)

Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, et al

Mechanism 1: Glutathione Peroxidase (GPx) - The Thyroid's HO Scavenger The glutathione peroxidase (GPx) enzyme family - particularly GPx1, GPx3, and GPx4 - uses glutathione as its essential substrate to neutralize HO in thyroid cells