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Description

SCFAs exert anti-inflammatory effects by inhibiting NLRP3 inflammasome activation, whereas TMAO triggers this pathway [37]

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Pharmacological IRE1 inhibition de-sensitizes cells to ferroptosis As the RNase activity of IRE1 can be inhibited pharmacologically 24 , we tested the effect of specific IRE1 RNase inhibitors including 48c 19 and MKC9989 25 , on erastin-induced ferroptosis

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