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References 1 AdessoS.MagnusT.CuzzocreaS.CampoloM.RissiekB.PacielloO.et al

485 Indeed, in a preliminary study, deferiprone treatment for 12 months (30 mg per kilogram per day) in patients with early-stage PD experienced a decrease in both substantia nigra iron deposits and motor-scale indicators of disease progression

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To mechanistically determine whether 15LO1 pathway activation alters the intracellular redox balance, particularly under T2 conditions, these ex vivo findings were modeled in vitro in primary HAECs

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This cell death form depends on iron rather than other metals, and can be suppressed by iron chelator deferoxamine (DFO)