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Studies involving dermal fibroblasts suggest that copper peptides may enhance the expression of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), thereby supporting balanced extracellular matrix (ECM) turnover

The applicant asserted that the Axoguard HA+ Nerve Protector TM demonstrates clinical improvement in: (1) nerve health in an injured tissue bed through less adhesion, extraneural scarring, and inflammatory markers, (2) nerve health in an injured tissue bed through decreased friction between the nerve and surrounding tissue to allow for gliding and to minimize potential for soft tissue attachment, (3) device performance due to its sodium hyaluronate and sodium alginate gel layer that allows for nerve gliding, and (4) sensory and motor symptoms

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A dual Annexin V staining/PI flow cytometry assay revealed that AP probe-net significantly enhanced apoptosis in the late stage (Annexin V+/PI + channel), which can be stained by both Annexin V and PI

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