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60,61 Overview of ferroptosis Ferroptosis is a cellular response to oxidative stress that depends on excess iron, phospholipids (PLs) with polyunsaturated fatty acid chains (PUFAs), and ROS

There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

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doi: 10.1016/j.immuni.2017.02.013 263 WatanabeD.UchiyamaK.HanaokaK

doi: 10.1177/0300985820913265 12 LongneckerRMKieffECohenJI