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Eitinger, T., J

Gradient chemokines, growth factors, or other ligands at the front side can facilitate the cells by recruiting PIK3CA kinase and the small GTPase proteins such as Rac and CDC42 to the cell front, thereby promoting adhesion formation with downstream multiple signaling pathways such as PIK3CA/AKT/GSK (glycogen synthase kinase) signaling pathways [61]

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Drug interactions with prescription medications are also a significant concern