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10.1007/s00401-009-0619-8 114 SpickettC

Braz J Plant Physiol 17(1):3552

Remember that supplements complement, but don't replace, fundamental health practices like maintaining healthy weight, limiting alcohol intake, eating a nutrient-dense diet, and managing metabolic health

The toxic anthraquinones and their metabolic activation are clearly shown in Table 1

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The results showed that the PD-1 inhibitor significantly increased ROS and MDA levels (Figures 6B, C) and decreased the activity of the antioxidant enzyme SOD in HCAECs (Figure 6D), indicating that the PD-1 inhibitor caused ROS accumulation and oxidative stress in ECs