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The goal is the minimum effective dose, not the maximum tolerable dose

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GLP-1 receptor agoniststhe class of drugs that includes semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)are synthetic molecules engineered to mimic and amplify this exact hormonal signal

The second barrier to an amylin-analog drug was to extend the half-life relative to the first-generation drug, pramlintide, which is injected 3 times daily