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Mechanism: VEGF pathway modulation promoting physiological angiogenesis and endothelial protection, anti-inflammatory effects reducing vascular damage

A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

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A previous study revealed a positive association between copper levels and the progression of atherosclerosis (59)

K.), the Lundbeck Foundation (to S.G.F.R.), the National Institute of Neurological Disorders and Stroke (grant RO1-NS28471 to B.K.) and the Mather Charitable Foundation (to B