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Metformin lowers blood sugar, reduces liver glucose production, and improves insulin sensitivity

User 3 split his 500mcg dose as 250mcg every 12 hours specifically to account for what he cited as a 4 to 6-hour half-life

Unlike immunosuppressive drugs, TB-500 modulates rather than eliminates inflammatory responses

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In human monocytes, which do not express TLR7, 2O-methylated RNA also significantly reduces TNF- and IL-12p40 expression, likely due to the absence of TLR8 activation