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Impaired detoxification and toxin accumulation: Toxins and heavy metals build up in tissues when glutathione-dependent detox pathways fail

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Approximately 10%20% of HGSOCs have BRCA1 promoter methylation, which is an important risk factor (Lnning et al., 2022)

Oncotarget 5(15):60876101 Leone RD, Zhao L, Englert JM et al (2019) Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion