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Agonistic antibodies reveal the function of GPR56 in human glioma U87-MG cells

Preclinical acute toxicity is low, with reported rodent LD50 values well above any human-equivalent research dose

However, as the development of multi-specific protein therapeutics becomes more widespread, the potential for immune complex formation and consequent immunogenicity must be considered, as the latter can lead to both loss of pharmacodynamic activity and safety concerns

Genetic analysis reveals AMPK is required to support Tumor Growth in Murine Kras-Dependent Lung Cancer models

The Mg 2+ -bound enzyme is catalytically active, while a low Mg 2+ state may permit small molecule inhibition at the allosteric site (Extended Data Fig