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Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

doi: 10.3390/CANCERS6020771 239 Rojo de la VegaMChapmanEZhangDD

Furthermore, macrophages were polarized into M1 (IFN- and LPS) or M2 (IL-4/IL-13) phenotypes, with and without IGFBP7 silencing

Studies suggest that O 2 - and H 2 O 2 serve as inflammasome activating ROS, enhancing the activation and production of NLRP3 inflammasome in mouse glomeruli cells

These risks highlight the need for individualized assessments before intervention, standardized dosing and duration, and long-term safety monitoring to ensure clinical applicability and minimize potential harms

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