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Description

It works by binding directly to the IGF-1 receptor (IGF-1R) on muscle and other tissue, activating the PI3K/Akt and MAPK signaling cascades that drive cell growth and proliferation

Proteins and their regulators in human disease

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Additionally, accelerated ATP degradation under pathological conditions (e.g., intense exercise and ischemiareperfusion injury) promotes hypoxanthine accumulation, creating a secondary drive for UA overproduction (Uskudar Cansu et al., 2019)

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