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Even with such a large contact area, capillary ECs in the CNS, unlike those in most peripheral organs, lack small pores that would allow polar solutes to pass through the barrier because of the presence of tight junctions (TJs)

First, molecules normally processed by the MTHFR enzyme (such as MeTHF and folate) can accumulate to undesirable levels

Immunol 17, 14591466 (2016)

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This may in part be due to a so-called addiction transfer, which may occur as a potential coping mechanism in mental illness (91)

(Source 1) "Glutathione deficiency correlates with chronic disease and can be replenished from exogenous sources, such as natural glutathione in food and glutathione supplements." 10 Best Food That Contains Glutathione Dietary protein provides the building blocks for glutathione production, but you can also directly get glutathione from plant foods