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TANK-binding kinase 1 (TBK1) is a protein kinase tightly regulated by dimerization, ubiquitination, and phosphorylation [23,24,25]

366 Stem cells and stem cell-derived exosomes have shown immunomodulatory effects on DKD, diabetic cardiomyopathy, DR, and DFU, involving the regulation of macrophage polarization, the inflammatory balance, and Tregs (Table S2)

Because the APAP oxidation occurs predominantly in the liver and kidneys, both organs can exhibit significant impairment or even failure after APAP overdose (Kennon-McGill and McGill 2018

Specifically, A-induced signalling, mediated through the integrin 1 receptor, Src-family kinase Fyn, and Ca 2+ /CaMKII pathways, promotes the differentiation, maturation, and survival of oligodendrocytes

However, it still reaches the ENS, where it causes neuronal damage [120]