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Revollo JR, Grimm AA, Imai SI (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

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PLoS ONE 7 , e40015 (2012)

These contrast with homeostatic levels (0.11 mM in humans/mice), establishing low (1 mM) and high (2 mM) thresholds for context-dependent function

16 Despite increases in NAC concentrations, there was no observed increase in CSF total or reduced GSH concentrations, presumably because the conversion of NAC to GSH occurs intracellularly