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Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

FEBS Lett 318:3034 Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No

Sparganium stoloniferum , the 14th component of the formula, is rich in phenylpropanoids such as ferulic acid, caffeic acid, and p-Coumaric acid