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The reduction of NOx urinary excretion and the high concentration of nitrotyrosine in the rats plasma and organs exhibited that an interaction between nitric oxide (NO) and ROS could contribute to the pathogenesis of hypertension in BSO-treated rats (Eiserich et al., 1995)

In AD and PD, astrocytes internalize proteopathic species but often become overwhelmed and contribute to spreading pathology by releasing inflammatory signals (106)

Available from: /pmc/articles/PMC8621732/ 592

Activated charcoal with or without gastric lavage may be administered if severe signs are expected

Il24 / mice on a C57BL/6N genetic background were originated from The Jackson Laboratory

Conclusion: Our work is the first to identify hepatocyte apoptosis and NLRP3 inflammasome activation as drivers of ILICI