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155,174 A meta-analysis of 16 randomized controlled trials conducted in countries around the world with varying fortification policies found combined B-vitamin therapy that included folic acid at doses close to 800 mcg daily was more effective for lowering homocysteine levels than single B-vitamin therapy

Pennone V, Angelini E, Sarlah D, Lovati AB

Large-scale and long-term clinical trials are essential to resolve these concerns

If we can't make 5-MTHF, we can't turn homocysteine back into methionine, and homocysteine builds up in the blood