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doi: 10.1016/j.mehy.2009.12.020 75 Panner SelvamMKAgarwalAHenkelRFinelliRRobertKAIovineCet al

In vitro studies provide further mechanistic insight, showing that lithium enhances mitochondrial function, supports oxidative balance, and prevents apoptosis through mechanisms involving cytochrome c regulation, Bcl-2 modulation, and preservation of complex I activity