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Berberine mitigates microglial activation and promotes neuroprotection by blocking the TLR4/NF-kB pathway (Tian et al., 2023)

doi: 10.1111/bdi.12980 114 DimopoulosNPiperiCPsarraVLeaRWKalofoutisA

doi: 10.1039/C8CC02669F 22 LanttoR.PuolanneE.KruusK

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Lipidomic analyses indicate that phosphatidylethanolamines (PEs) containing arachidonic acid (AA) or adrenic acid (AdA) are key membrane phospholipids and are further oxidized to phospholipid hydroperoxides (PE-AA/AdA-OOH) by non-enzymatic processes, such as the above mentioned free radical lipid peroxidation or Fenton chemistry drives ferroptosis (Doll et al., 2017

Mo et al., 2016), which decreased as RPCs differentiated into photoreceptors, and are accompanied by increased expression (Solovei et al., 2009)