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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

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Inhibiting NNMT with 5-Amino-1MQ preserves intracellular NAD+ levels, which supports mitochondrial function and has been shown in rodent models to reduce adiposity and improve insulin sensitivity

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A p-value less than 0.05 was considered statistically significant, indicating a meaningful difference in treatment efficacy

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