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The SIRT1/HIF2alpha axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy

These results suggest that both low and high copper levels induce oxidative stress, with HepG2 ATP7B-KO cells being more sensitive under physiological copper conditions

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Additional studies also report that chronic inflammation impairs key intracellular signaling cascades, such as PI3K/Akt and mTOR, in granulosa cells, thereby promoting ROS accumulation and impairing follicular maturation (Gonnella et al., 2022)