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doi: 10.1186/s40104-022-00715-1 3 GaoYZhaoSZhangYZhangQ

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With aging, ECs undergo profound metabolic reprogramming, including disrupted glycolysis, mitochondrial dysfunction, and altered redox homeostasis

Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss

Gut microbiota as a promising therapeutic target for age-related sarcopenia

Compared with earlier versions of EGFR inhibitors, AZD9291 continued to inhibit the EGFR/ERK pathway, leading to an improved response in their murine models and an increase in OS (140)