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Another study found that the serum levels of the proinflammatory cytokine IL-6 were decreased, whereas that of the brain-derived neurotrophic factor (BDNF) were significantly increased after the use of multiple probiotics (228)

Supernatant fractions were then centrifuged (20,627 g for 10 minutes, 4C) and a 1 ml aliquot was removed and stored on ice

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197 Healthy carriers of the ZIP8 variant exhibited changes in intestinal microbiota that partially overlapped with those observed in CD patients