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It is believed, however, that inhibition of MAO-A is necessary for antidepressant effects.24,25 The mechanism of available therapies for MDD is based on the principle of increasing synaptic availability of serotonin, norepinephrine, and/or dopaminethe monoamine neurotransmitters.26,27 The MAOIs inhibit the MAO enzyme, thereby allowing serotonin, norepinephrine, and dopamine to accumulate in the synapse.27,28 The MAO-A isoenzyme metabolizes serotonin, norepinephrine, and dopamine, while MAO-B primarily metabolizes dopamine

For patients exhibiting low hormone sensitivity but significant OS damage, the focus should shift toward antioxidant therapy while appropriately adjusting the intensity and modality of hormone intervention

Some studies, however, have not found the effect (188, 219)

Metformin (0.5 M), IACS-010759 (10 nM) and oligomycin (10 nM) were added and plates were incubated for two weeks

28 NakaoA.RoijerE.ImamuraT.SouchelnytskyiS.StenmanG.HeldinC