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doi: 10.1146/annurev-pathol-012513-104715 26 VoliniaSCalinGALiuCGAmbsSCimminoAPetroccaFet al

A second treatment was performed affording him another 10 months of relief

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BH 4 acts as a lipophilic antioxidant similar to CoQ10, preventing lipid peroxidation and remodeling lipid membranes to increase reduced CoQ10 while decreasing PUFA-PLs ( Figure 2 ) ( 4 Iron metabolism and ferroptosis Iron is an important trace element involved in various cellular processes, such as erythropoiesis, oxygen transport, and energy metabolism

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Elevated CTP and GTP pools enable adequate DNA and RNA synthesis necessary for cancer cell proliferation and DNA repair in response to genotoxic stresses in multiple cancer types [81]