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Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus

Protective efficacy of piperine against Mycobacterium tuberculosis

Kosmalski M, Drzewoski J, Szymczak-Pajor I, Zieleniak A, Mikolajczyk-Solinska M, Kasznicki J, Sliwinska A (2022) Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

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Key Points 17-Hydroxylase/C17,20-lyase (CYP17) is a steroidogenic enzyme that is central to the production of androgens, and is targeted by abiraterone in men with castration-resistant prostate cancer Abiraterone is a promiscuous drug, interacting with numerous targets that include CYP11B1 and a panel of hepatic CYP enzymes