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Hence, individual simulated patients were created by keeping the reaction rates constant while scaling the abundance of proteins based on the fold change in the mRNA of each protein in the tumor compared to the same patients healthy tissue

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The drug loading efficiency was up to 69.95% and the disulfide linkage between the drug and SBA-15 provided the nanocarrier with redox-responsive capability for controlled drug release, and could be degraded by reducing agents such as dithiothreitol (DTT) or glutathione (GSH)

doi: 10.1016/j.bj.2018.03.004 45 FedorovaT

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The Isoelectric Point, pI, Is The pH At Which Negative and Positive Charges Are Balanced In practice, the zwitterionic amino acid will only have a net charge of zero at a very narrow range of pH values